The Wu Lab
Organic Synthesis & Catalysis
(Z)-2-(bromomethyl)-3-(hydroxymethylene)-7-methoxy-5-methyl-2-(tribromomethyl)-4-chromanone
Lee, C.-C.; Wu, Y.-K.*
Molbank 2025, 2025, M2023. (DOI: 10.3390/M2023)
- Invited contribution with full waiver of article processing charge
Minisci Reaction by an MW-Boost. A Simple Protocol for Site-Selective Dehydrogenative Cross-Coupling between Nitrogen-Aromatics and C(sp3)-H Bonds
Jou, S.-P.; Wu, Y.-K.; Fukuyama, T.; Fujii, S.; Ryu, I.*
Chem. Eur. J. 2025, 31, e202501135. (DOI: 10.1002/chem.202501135)
Coordination Chemistry and Reactivity of a Lewis Acidic Di‐Zinc Framework Supported by Bisphenoxymethanone Ligands
Wu, D.-H.†; Lin, X.-J.†; Benchaphanthawee, W.; Lee, Y.-H.; Lin, Z.-C.; Li, H.-J.; Chen, P.-L.; Kuo, T.-S.; Wang, C.-L.; Wu, Y.-K.*; Peng, C.-H.*; Liu, H.-J.* [†These authors contributed equally]
ChemPlusChem 2025, 90, e202400382. (DOI: 10.1002/cplu.202400382)
Palladium-Catalyzed Oxidative Cyclization of O-Aryl Cyclic Vinylogous Esters: Synthesis of Benzofuran-Fused Cyclohexenones
Yen, K.-W.; Chein, C.-C.; Wung, S.-H.; Shen, L.-C.; Wu, Y.-K.*
J. Org. Chem. 2024, 89, 18679-18683. (DOI: 10.1021/acs.joc.4c02167)
Chelation-Induced Zwitterion-Like Antifouling Behavior on Anionic Poly(3,4-ethylenedioxythiophene) Surfaces
Kao, T.-Y.†; Gong, Y.-C.†; Huang, C.-H.; Wu, Y.-K.*; Luo, S.-C.* [†These authors contributed equally]
Langmuir 2024, 40, 22417-22423. (DOI: 10.1021/acs.langmuir.4c03275)
A Concise Route to Keto-Bridged Polyphenols by Photo-Fries Rearrangement in Flow
Lin, X.-J.; Wang, C.-L.; Peng, C.-H.*; Liu, H.-J.*; Wu, Y.-K.*
Chem. Asian J. 2024, 19, e202400269. (DOI: 10.1002/asia.202400269)
- Invited contribution for the special issue: Early Career Researchers Joint Special Collection 2023/2024
Optimal Compositions in the NDI:Pyrene Charge-Transfer Complexes Revealed by Thermal Analysis and Structural Characterizations
Lin, H.-Y.; Zhong, B.-J.; Liu, H.-J.; Wu, Y.-K.; Peng, C.-H.; Wang, C.-L.*
Cryst. Growth Des. 2024, 24, 2833–2840. (DOI: 10.1021/acs.cgd.3c01482)
Protocol for the Photocatalytic Hydroxyalkenylation of Alkenes Using 1,2-Bis(phenylsulfonyl)ethylene and Water
Tsai, C.-Y.; Chen, C.-Y.; Wu, Y.-K.; Ryu, I.*
Helv. Chem. Acta 2024, 107, e202400017. (DOI: 10.1002/hlca.202400017)
Palladium-Catalyzed α-Arylation of Meyers’ Chiral Bicyclic Lactams and a Deprotonative Ring-Opening Sideline
Chiang, H.-L.†; Zhao, W.-T.†; Chen, Y.-A.; Lin, Y.-C.; Chen, P.-L.; Wu, Y.-K.* [†These authors contributed equally]
Synlett 2024, 35, 1145-1148. (DOI: 10.1055/a-2258-3788)
- Invited contribution for the special issue: Thieme Chemistry Journals Awardees 2023
Electron-Transfer Protocol for the Hydroxyalkenylation of Alkenes Using 1,2-Bis(phenylsulfonyl)ethylene
Tsai, C.-Y.; Jhang, Y.-J.; Wu, Y.-K.; Ryu, I.*
Angew. Chem. Int. Ed. 2023, 62, e202311807. (DOI: 10.1002/anie.202311807)
Tandem photo-crosslinking/sol–gel reaction for the green synthesis of morphology-alterable, redox-responsive silica particles
Chang. Y.-H.†; Huang, I-C.†; Huang, C.-Y.†; Wu, Y.-K.; Hsu, H.-Y.* [†These authors contributed equally]
Colloids Surf. A: Physicochem. Eng. Asp. 2023, 670, 131525. (DOI: 10.1016/j.colsurfa.2023.131525)
Photocatalytic Oxidative Cleavage of Alkenes by Molecular Oxygen: Reaction Scope, Mechanistic Insights, and Flow Application
Shih, Y.-L.; Wu, Y.-K.; Hyodo, M.; Ryu, I*
J. Org. Chem. 2023, 88, 6548-6552. (DOI: 10.1021/acs.joc.2c02429)
Manipulating the Distribution of Surface Charge of PEDOT toward Zwitterion-Like Antifouling Properties
Lin, T.-Y.†; Lo, W.-Y.†; Lin, C.-H.; Wu, Y.-K.*; Luo, S.-C.* [†These authors contributed equally]
Polymer 2022, 262, 125507. (DOI: 10.1016/j.polymer.2022.125507)
Photoinduced Arylation of Chloroarenes in Flow: Synthesis of Unsymmetrical Biaryls
Hong, Z.-S.†; Kao, S.-C.†; Cheng, Y.-T.; Chen, C.-J.; Wu, Y.-K.* [†These authors contributed equally]
Org. Biomol. Chem. 2022, 20, 8212-8216. (DOI: 10.1039/D2OB01710E)
- Highlighted by Synfacts - Flow Chemistry Series (Synfacts 2022; 18(12): 1388)
Revisiting the Synthesis of Bis(2-hydroxy-3,5-di-t-butylphenyl)methanone
Lin, X.-J.; Huang, S.-P.; Huang, M.-J.; Wang, C.-L.; Peng, C.-H.*; Liu, H.-J.*; Wu, Y.-K.*
J. Chin. Chem. Soc. 2022, 69, 1803-1809. (DOI: 10.1002/jccs.202200358)
Expansion of Photocatalytic C(sp3)-H Functionalization to Allylation, Alkynylation, and Imination
Shih, Y.-L.; Huang, S.-H.; Wu, Y.-K.; Ryu, I.*
Bull. Chem. Soc. Jpn. 2022, 95, 1501-1505. (DOI: 10.1246/bcsj.20220171)
Total Synthesis of (±)-Mersicarpine Following a 6-exo-trig Radical Cyclization
Peng, W.-L.; Jhang, Y.-J.; Chang, C.-Y.; Peng, P.-K.; Zhao, W.-T.; Wu, Y.-K.*
Org. Biomol. Chem. 2022, 20, 6193-6195. (DOI: 10.1039/D2OB00620K)
- Invited contribution for the New Talent issue
Site-Selective C(sp3)-H Alkenylation Using Decatungstate Anion as Photocatalyst
Wang, Y.-T.; Shih, Y.-L.; Wu, Y.-K.; Ryu, I.*
Adv. Synth. Catal. 2022, 364, 1039-1043. (DOI: 10.1002/adsc.202101374)
Total Synthesis of (±)-Taiwaniaquinol B through a Sequence of Fries Rearrangement and Photo-Nazarov Cyclization
Chang, C.-Y.†; Chen, C.-J.†; Huang, S.-H.; Kao, S.-C.; Wu, Y.-K.* [†These authors contributed equally]
Asian J. Org. Chem., 2022, 11, e202100721. (DOI: 10.1002/ajoc.202100721)
Haloarene-Guided Cascade Arylation of Cyclic Vinylogous Esters under Palladium Catalysis
Lin, Y.-C.; Yen, K.-W.; Lin, H.-J.; Yang, Y.-C.; Wu, Y.-K.*
Chem. Commun. 2021, 57, 12119-12122. (DOI: 10.1039/D1CC05006K)
Synthetic Routes to Crinine and Vittatine
Lin, Y.-C.; Wu, Y.-K.*
J. Chin. Chem. Soc. 2021, 68, 1812-1828. (DOI: 10.1002/JCCS.202100270)
- Selected as front cover art by the Editors (see here) / Top Downloaded Article in the Issues of 2021
Palladium-Catalyzed Substitution of Allylic Alcohols with Sulfinate Salts: A Synthesis of Bicalutamide
Jhang, Y.-J.; Chang, C.-Y.; Lin, Y.-H.; Lee, C.-C.; Wu, Y.-K.*
Tetrahedron Lett. 2021, 73, 153060. (DOI: 10.1016/j.tetlet.2021.153060)
Site-Selective Alkenylation of Unactivated C(sp3)−H Bonds Mediated by Compact Sulfate Radical
Ueda, M.; Kamikawa, K.; Fukuyama, T.; Wang, Y.-T.; Wu, Y.-K.; Ryu, I.*
Angew. Chem. Int. Ed. 2021, 60, 3545-3550. (DOI: 10.1002/anie.202011992)
Formal synthesis of schulzeines B and C: A new route to Gurjar's lactams
Chou, C.-E.; Chen, Y.-A.; Lin, Y.-C.; Kao, S.-C.; Chang, C.-Y.; Wu, Y.-K.*
J. Chin. Chem. Soc. 2020, 67, 2198-2203. (DOI: 10.1002/JCCS.202000216)
- Invited contribution for the 18th Asian Chemical Congress Special Issue
Photo-Fries rearrangement in flow under aqueous micellar conditions
Chien, C.-C.; Kao, S.-C.; Chen, C.-J.; Wu, Y.-K.*
Chem. Commun. 2020, 56, 15470-15472. (DOI: 10.1039/D0CC07331H)
- Highlighted by Synfacts - Flow Chemistry Series (Synfacts 2021; 17(02): 0231)
Pd/light-induced alkyl–alkenyl coupling reaction between unactivated alkyl iodides and alkenylboronic acids
Huang, H.-J.; Wang, Y.-T.; Wu, Y.-K.; Ryu, I.*
Org. Chem. Front. 2020, 7, 1266-1270. (DOI: 10.1039/D0QO00318B)
Palladium-catalyzed α-arylation of indolin-3-ones
Chang, Y.-H.; Peng, W.-L.; Chen, I-C.; Hsu, H.-Y.; Wu, Y.-K.*
Chem. Commun. 2020, 56, 4660-4663. (DOI: 10.1039/D0CC00435A)
Palladium-Catalyzed Cascade Arylation of Vinylogous Esters Enabled by Tris(1-adamantyl)phosphine
Yang, Y.-C.; Lin, Y.-C.; Wu, Y.-K.*
Org. Lett. 2019, 21, 9286-9290. (DOI: 10.1021/acs.orglett.9b03071)
- Selected as front cover art by the Editors (see here)
Rapid construction of tetrahydropyridine scaffolds via formal imino Diels–Alder reactions of Schiff bases and Nazarov reagents
Wu, Y.-K.*; Rawal, V. H.*
Org. Biomol. Chem. 2019, 17, 8827-8831. (DOI: 10.1039/C9OB01880H)
Revisiting Hydroxyalkylation of Phenols with Cyclic Carbonates
Kao, S.-C.; Lin, Y.-C.; Ryu, I.; Wu, Y.-K.*
Adv. Synth. Catal. 2019, 361, 3639-3644. (DOI: 10.1002/adsc.201900287)
Palladium-catalyzed N1-selective allylation of indoles with allylic alcohols promoted by titanium tetraisopropoxide
Chang, C.-Y.; Lin, Y.-H.; Wu, Y.-K.*
Chem. Commun. 2019, 55, 1116-1119. (DOI: 10.1039/C8CC09817D)
Temperature-Controlled Thiation of α-Cyano-β-Alkynyl Carbonyl Derivatives for De Novo Synthesis of 2-Aminothiophenes and Thieno[2,3-c]isothiazoles
Kao, T.-T.; Peng, B.-K.; Liang, M.-C.; Lee, C.-J.; Chen, I-C.; Shia, K.-S.*; Wu, Y.-K.*
J. Org. Chem. 2018, 83, 14688-14697. (DOI: 10.1021/acs.joc.8b01866)
Palladium-Catalyzed α-Allylation of Secondary Nitroalkanes with Allylic Alcohols and Strategic Exploitation of Seebach’s Reagent for the Total Synthesis of (±)-Adalinine
Chang, C.-Y.; Wu, Y.-K.*
J. Org. Chem. 2018, 83, 6217-6224. (DOI: 10.1021/acs.joc.8b00710)
- Highlighted by J. Org. Chem. Global Enterprise 2019 (Virtual Issue)
Electron transfer-induced reduction of organic halides with amines
Fukuyama, T.; Fujita, Y.; Miyoshi, H.; Ryu, I.*; Kao, S.-C.; Wu, Y.-K.*
Chem. Commun. 2018, 54, 5582-5585. (DOI: 10.1039/C8CC02445F)
Palladium/Light Induced Radical Alkenylation and Allylation of Alkyl Iodides Using Alkenyl and Allylic Sulfones
Sumino, S.; Uno, M.; Huang, H.-J.; Wu, Y.-K.; Ryu, I.*
Org. Lett. 2018, 20, 1078-1081. (DOI: 10.1021/acs.orglett.7b04050)
A Combined Tamaru Allylation/Olefin Cross-Metathesis Approach for the Total Syntheses of (±)-Paniculidine B, (±)-Paniculidine C, and 2-Methylcarbazole
Tseng, Y.-L.; Liang, M.-C.; Chen, I-C.; Wu, Y.-K.*
Synlett 2018, 29, 609-612. (DOI: 10.1055/s-0036-1591739)
Palladium-Catalyzed α-Arylation of Cyclic Vinylogous Esters for the Synthesis of γ-Arylcyclohexenones and Total Synthesis of Aromatic Podocarpane Diterpenoids
Hou, W.-Y.; Wu, Y.-K.*
Org. Lett. 2017, 19, 1220-1223. (DOI: 10.1021/acs.orglett.7b00268)